Korean Red Ginseng Could Aid Against Residual Symptoms of Depression

Updated: Oct 14, 2020

The study suggests that Korean Red Ginseng can help relieve the common side effects of antidepressant medication.
General Information
  • 12 Dec 2014
  • South Korea
  • Korea University College of Medicine
  • Jeong, H. G. et al.
  • Clinical trial
  • 35 females
  • 8 weeks

Close to 20% of patients who suffer from major depression can also experience residual symptoms - that is, less severe but persistent symptoms that refuse to go away with treatment, most often insomnia or appetite problems. In past studies, ginseng has sparked hope of being a valuable resource as an antidepressant, as results have had a clear potential for relief in animals and in patients with stress-related symptoms. A team of researchers in Seoul, Korea has decided to begin testing the effects of Korean Red Ginseng (a regional variety of Panax ginseng) in patients with residual symptoms of major depression.

The Study

For eight weeks, three grams of Korean Red Ginseng were given to thirty-five female outpatients aging from 18 - 65 years each day. These patients had been remitted from major depression with residual symptoms. Several scales were used in measuring the effectiveness of ginseng, including the Depression Residual Symptom Scale (DRSS), the Montgomery-├ůsberg Depression Rating Scale (MADRS), the Clinical Global Impressions Scale for Severity (CGI-S), and the Depression and Somatic Symptom Scale (DSSS). Clinicians used these scales to evaluate both psychological and physical symptoms and to measure their severity.

The Results

At the end of eight weeks, participants in the study showed significant improvement on all four scales. Both depressive and bodily symptoms diminished, and the severity of the illness, measured objectively, also decreased.

What This Means

The results of this study inspire similar hope as past studies on ginseng - that relief from symptoms of major depression is not only possible, but available through a natural resource. Korean Red Ginseng could prove itself to be a vital, effective, and affordable addition to a regimen of other antidepressant methods, potentially minimizing the depression itself, as well as its residual symptoms. However, more testing is required - especially larger studies that include a placebo-controlled group - before ginseng can be used confidently by patients with depression.


  • Asia-Pacific Psychiatry, Effect of Korean Red Ginseng as an adjuvant treatment for women with residual symptoms of major depression, 2014