Pepino is an ancient Andean fruit that has so far been grown mostly for local consumption, but it's becoming more and more commercially popular for its mild flavor and health properties.

Fact checked

By HerbaZest Editorial Team | Updated: Jan 31, 2023

General Information
  • Common name(s) Sweet pepino, pepino melon, melon pear, melon shrub, pear melon, pepino dulce
  • Scientific name Solanum muricatum
  • Plant type Shrub
  • Native region South America
  • Main producer(s) Chile, New Zealand, Peru, United States of America, Colombia
  • Main Economic Use Culinary

The pepino fruit, also known as pepino melon, has been grown widely in the Andes for centuries. Highly valued for its light, melon-like taste as well as its nutritional value, it became a staple of the Incan diet. In fact, it was so popular that all naturally-occurring pepino varieties were used for food or cultivation, and no known wild strains remain. Until recently, the plant was not widely grown outside of the South American countries where it is native. However, in recent years, it has been gaining commercial popularity as its health benefits have become better known. 

Pepino Medicinal Properties

Quick Facts
  • Medicinal action Diuretic, Hypoglycemic
  • Key constituents Phenolic compounds, flavonoids
  • Ways to use Food
  • Medicinal rating (2) Minorly useful plant
  • Safety ranking Safety undetermined

Health Benefits of Pepino

While pepino was originally cultivated for its taste and its refreshing fluid content, its recent increase in international popularity has also been partially due to its medicinal uses, which include:

  • Regulating glucose levels. Pepino has been found to help keep blood sugar at a manageable level, as well as to improve the efficacy of insulin.

  • Stimulating urination. Pepino has been traditionally used as a diuretic, and this is one of its best-known attributes.

Additionally, the strong antioxidant properties in pepino help prevent cellular decay, an effect that is thought to be especially beneficial to the heart. Pepino fruit also provides good amounts of vitamins A, B, C, and K, as well as minerals such as iron, zinc, copper, manganese, calcium, potassium, and phosphorus.

How It Works

The pepino plant contains several phenolic compounds, such as caffeic acid, cinnamic acid, coumaric acid, ellagic acid, ferulic acid, and rosmarinic acid, as well as flavonoids such as epicatechin, myricetin, naringenin, quercetin, and rutin. Both of these groups are essential for the pepino's antioxidant properties, which benefit cardiac and metabolic functioning.1,2 However, the mechanisms behind these benefits are still under study.

Pepino consumption has been shown to regulate key metabolic enzymes, and it is considered as an effective functional food for type 2 diabetes.2

Lucuma and yacon are herbs with a significantly low glycemic index that also contribute to reducing blood sugar levels in people with hyperglycemia and diabetes, whereas blueberry and green tea possess potent antioxidant actions.

Pepino Side Effects

Pepino is believed to be mostly safe for oral consumption. However, it has very high levels of iodine, so consuming too much pepino could result in iodine toxicity - which causes nausea, increased salivation, and a metallic taste in the mouth - in those sensitive to the element. Pepino is not known to have any other side effects, but it has not been extensively studied, so the knowledge of its potential side effects is incomplete. 

Pepino Cautions

The iodine content of pepino, if the fruit is overconsumed, may also cause medical interactions with certain drugs, including lithium, warfarin, and thyroid medications. Pepino may also worsen liver damage, particularly alcohol-induced damage, and should be avoided by those suffering from liver disease. As always, a doctor's advice should be sought before beginning any regimen of herbal supplements, especially for pregnant or breastfeeding women.

Pepino Benefits and Properties

How to Consume Pepino

Quick Facts
  • Edible parts Fruit
  • Edible uses Beverage
  • Taste Sweet, Mild

While pepino has several medicinal properties, it currently has no medicinal forms of consumption. Instead, it is commonly used in cooking, which provides all of its health benefits.

Natural Forms

Pepino can be eaten raw, alone or in salads, or it can be cooked and added as an ingredient to other dishes. It is also available canned or preserved. Generally, the pepino is eaten without its skin, as many varieties of this fruit have skins with a bitter, unpleasant taste.

How to Use Pepino


Quick Facts
  • Where to buy Supermarkets, Farmers' markets

Natural Forms

Pepino is gaining popularity worldwide and is likely to become easier to find around the world. It is generally sold fresh and raw, like many other fruits and vegetables. Fresh pepino fruits are most likely to be available in grocery stores, and it may be found in local markets as well, depending on location. They are widely available in South America. 


Quick Facts
  • Life cycle Perennial
  • Harvested parts Fruit
  • Light requirements Full sun, Partial shade
  • Soil Light (sandy), Well-drained
  • Soil pH 6.6 – 7.3 (Neutral)
  • Growing habitat Temperate climates, Andean region, Warm climates
  • Planting time Spring
  • Plant spacing average 1 m (3.28 ft)
  • Propagation techniques Cuttings
  • Potential insect pests Aphids, Mites, Nematodes, Whitefly, Colorado potato beetles, Cutworms, Flea beetles, Leafminers
  • Potential diseases Leaf spot, Root rot, Anthracnose

The pepino is adaptable to many different altitudes and longitudes, so it can be grown in many places around the world. If planted in the right conditions, pepino can be an ideal garden plant. It is easy to grow, and its fruits are ready to consume as soon as they are harvested. There are some challenges when growing a pepino plant, but a bit of effort will earn success. 

Growing Guidelines

  • Cuttings are the advised method of propagation for pepino, and they should be placed two to three feet (1 m) apart when planted.

  • Pepino cuttings should be planted in moist soil with good drainage. Pepino plants grow well in poor soil, and in fact, the soil should not be too rich, as over-fertilizing pepino plants can reduce their quality.

  • It is advised to find a spot with full sun to partial shade that is sheltered from strong winds in order for the pepino plant to thrive.

  • The pepino plant does best in soils with a neutral pH, within a range of 6.5 - 7.5. They can survive in soils with a slightly higher pH, but cannot tolerate more acidic soil. This plant similarly cannot tolerate salinity.

  • Pepino fruits mature in summer and require temperatures above 26°F (-3°C). However, any temperature above 86°F (30°C) reduces the sugars in the growing fruit and results in lower-quality produce.

  • Pepino has little drought resistance and should be kept moist with frequent watering

  • The pepino plant grows tall and tends to branch out, and it may require a trellis or other form of support to prevent the fruits from weighing down the stem. 

  • Pepino is a perennial plant, but it is often raised as an annual because fruit yield decreases significantly after two fruiting seasons

  • Because the pepino plant has a long period of flowering and fruiting - from two to three months - many gardeners raise pepinos in greenhouses rather than risk losing the fruits to short or cold summers. 

  • Some pests may damage the pepino plant, notably aphids, mites, and whitefly.

Additional Information

Quick Facts
  • Other uses Cosmetics

Plant Biology

Pepino is an herbaceous perennial plant with an abundance of foliage and thin branches. In appearance, it is similar to the tomato plant, growing to a height of two to three feet (1 m). Pepino's small, bright green leaves grow in pairs, and there are usually one to three pairs of leaves on each stem. Its flowers are small and range in color from blue or purple to white with purple markings. The fruit begins as a light green and slowly turns yellow with purple stripes and spots as it ripens. The flesh of the fruit is usually white or pale yellow. 

The pepino plant, Solanum muricatum, has several other colloquial names, including sweet pepino, pepino melon, melon pear, melon shrub, and pear melon, despite no close relations to either melons or pears. In Spanish, the word pepino generally refers to cucumber, and so S. muricatum is commonly called pepino dulce (sweet pepino) in order to make a clear distinction between the two.

  • Classification

    Botanically classified as Solanum muricatum, the pepino plant is a member of the Solanaceae family, which consists of 98 genera and over 2,700 species. This family of flowering plants is also known as the nightshade family, and includes species of great economical importance, such as bell pepper (Capsicum annuum), eggplant (Solanum melongena), potato (Solanum tuberosum), and tomato (Lycopersicon esculentum). 

  • Cultivars of Pepino and Related Species

    Because Solanum muricatum has been grown by humans since at least the 15th century, several different cultivars have been developed over the years. Some strains, particularly in the South American countries where the plant grows naturally, have not been named. However, other cultivars grown in other countries have been engineered and given names. New Zealand is known for growing the 'El Camino' and 'Suma' varieties, while California in the United States grows mostly the 'New Yorker' and 'Miski Prolific' types.

    There are not currently any wild species of pepino. The process by which it was domesticated is not fully understood, but it appears to have caused the extinction of the plant in the wild (with the exception of escaped domestic plants). However, S. muricatum is also closely related to S. caripense, a plant which does grow naturally in the wild. Although S. caripense does not produce desirable fruit on its own, the two plants together can produce hybrid offspring that grow edible fruits. 

Historical Information

It is not known when cultivation of the pepino plant began, but it was important and widespread throughout the Incan Empire when the Spanish conquerors arrived. Amulets, drinking vessels, and other ornamental pottery have been found molded in the shape of the pepino, demonstrating its significance to the Incan people. The Spanish introduced the fruit to Europe in the 18th century, but since then, the pepino has mostly been grown in South American countries and has not been a popular exported good. Only recently has interest in the pepino grown, and now it is becoming a trendy addition to salads and other dishes in many parts of the world, especially Japan

Economic Data

Pepino has recently begun to be a commercially-grown crop in countries outside of its natural habitat. South America remains one of its largest producers, along with the United States and New Zealand. It is a popular food item in those countries and is becoming especially popular in Japan, where it is sold in high-end, trendy stores and restaurants. However, because it is such a new commercial crop, not much in-depth economic data is yet available.

Other Uses

  • Gardening. Its unique appearance and surprisingly strong, fresh aroma make it an excellent choice for an ornamental addition to a fruit basket or another household decoration.

  • Cosmetics, such as facemasks, may also contain pepino because of its antioxidants and refreshing scent, but it is not a common cosmetic ingredient. 

The pepino fruit is a healthy and, according to many, delicious addition to most diets. It can be grown at home with a little effort, but it is also beginning to be available worldwide thanks to increasing interest in its glucose regulation and antioxidant properties.


  • American Indian Health and Diet Project, Foods Indigenous to the Western Hemisphere, Pepino
  • California Rare Fruit Growers, Pepino Dulce
  • Hawaiian Ecosystems at Risk, Solanum muricatum
  • Integrative Medicine, p. 315
  • International Journal of Molecular Sciences, The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury, 2016 | Phenolic Profile and Biological Activities of the Pepino (Solanum muricatum) Fruit and Its Wild Relative S. caripense, 2016
  • International Plant Genetic Resources Institute, Descriptors for Pepino, Solanum Muricatum
  • ISRN Obesity, Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice, 2012
  • Lost Crops of the Incas, pp. 297 - 305
  • Perennial Vegetables, p. 189
  • Prairie View A&M University, Pepino Fruit
  • Purdue University, Pepino (Solanum muricatum)
  • University of California, Davis, Pepino


  1. Journal of the Science of Food and Agriculture. (2011). Protective effects of an aqueous extract from pepino (Solanum muricatum Ait.) in diabetic mice. Retrieved January 30, 2023, from:
  2. Journal of Food Science. (2012). Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice. Retrieved January 30, 2023, from: